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One is a blood vessel issue, the other is a pigment-producing cell (melanocyte) issue

Aresti Sanz, J
It also decreases osteoblast autophagy, leading to increased osteoblast apoptosis (Schiavi et al., 2021) and the activation of endoplasmic reticulum stress, which results in reduced osteoblast formation and reduced matrix mineralization (Gavali et al., 2019

Kosower EM, Pazhenchevsky B and Hershkowitz E

3B and Additional file 1: Fig

Nitric oxide in the kidney: synthesis, localization, and function
