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these neurons utilize -aminobutyric acid as their neurotransmitter and send inhibitory projections to the deep cerebellar nuclei, and constitute the sole output of all motor coordination in the cerebellar cortex
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The key word is cumulative

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Skipping dose levels (e.g., jumping from 0.6 mg to 1.8 mg) should be avoided, as this significantly increases the risk of adverse events
