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Furthermore, pediatric patients with Kashin-Beck disease also benefit from regular selenium supplementation, which could improve radiographic structures (OR: 0.13, 95% CI: 0.04, 0.47) (42)

The ratio of Firmicutes to Bacteroidetes is a commonly-studied change with an increase often linked to HFD consumption/obesity in mice 43,44 and humans 45,46 (for review, see John and Mullin, 2016 47 )

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Cytokines such as IL-17, IFN-, and TNF- damage endothelial function and increase vascular stiffness