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APOE comes in four variants: APOE1 (extremely rare and not considered further), APOE2 (rare), APOE3 (most common), and APOE4 (common) ( APOE4 is evolutionarily the oldest ( APOE variant one carries affects tau and alpha-synuclein levels (Huynh et al., 2017

doi: 10.1016/j.fct.2014.10.005

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