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In a comprehensive study conducted by (Dong et al., 2022), the application of HRW (20%, 60%, 100%
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

However, recent advancements in oral formulations have narrowed this efficacy gap

161 Additionally, a Clostridium -derived metabolite, trimethylamine N-oxide, can activate the endoplasmic reticulum stress kinase protein kinase RNA-like endoplasmic reticulum kinase, leading to gasdermin E-mediated pyroptosis in tumor cells and promoting CD8 + T-cell-driven antitumor responses

RDA, recommended dietary allowance
Treatment response prediction : personalizing drug regimens based on patient profiles ( Wearable sensors and smartphones now enable real-time symptom tracking, and ML algorithms can stratify patients for adaptive trial designs and biomarker discovery (Figure 6)
