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Importantly, its protection effect was even confirmed in primary human hepatocytes [126]

Although many of the genes up- and downregulated by GSTP1 deletion are associated with the RAS/MAPK pathway (Supplementary Table 1), we did not detect a significant difference in RAS/MAPK pathway activation, using a quantitative RAF-1- binding/Ras GTPase ELISA to assess pathway activation in GSTP1 knockdown cells (data not shown)

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Winterbourn and Kettle, 2013)

Mitophagy and NAD(+) inhibit Alzheimer disease

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