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Circulation 88 : 14631469

doi: 10.1055/s-0035-1544237

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For the treatment of complex UTIs, including pyelonephritis, and cIAIs brought on by sensitive GNB such E

These cells are also specialized to recognize bacterial-derived molecules, known as prokaryotic-associated molecular patterns, with the help of the Toll-like receptors on the cell surface and the nucleotide-binding oligomerization domain-like receptors in the cytoplasm, which activate defense mechanisms by the secretion of anti-microbial peptides 2

In studies using obese murine models, AOD9604 administration was associated with increased lipolysis that coincided with elevated 3-AR mRNA expression, supporting the hypothesis that the peptide sensitizes fat cells to lipolytic signaling rather than simply forcing fat breakdown through a separate pathway