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Etter 36 mneder med vedvarende smerte skjer det nevrologiske endringer sentral sensitisering der nervesystemet blir hypersensitivt og sender smertesignaler selv uten proporsjonal vevsskade

Consequently, there is an increase in intestinal permeability and translocation of intestinal flora, leading to the release of enterogenic endotoxins into the bloodstream which act on the original organ via the circulatory system, further exacerbating deterioration of the intestinal organ

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Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression

Researchers continue to explore how these peptides, each operating through distinct biological mechanisms, may function together in experimental models focused on repair signaling, structural remodeling, angiogenesis-related pathways, and skin-associated biochemical processes

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