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These bone-marrow cells can be injected at any area in the body under image-guidance, and they also have good evidence for helping repair and rebuild osteonecrosis, avascular necrosis, bone marrow failure, spine and disc injuries, and subchondral defects in bones and joints [168-178, 194-197], which provides immense hope for patients with these recalcitrant and refractory conditions

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Despite the issues and challenges summarized above, we should take full advantage of nanotechnology and overcome these hurdles

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