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The significance of timing in combination therapy was brought to light by a study conducted by Eastwood et al., which showed that in a model of electrode insertion trauma, sequential delivery of dexamethasone and NAC was more efficacious than simultaneous delivery [4]

In addition, a lower intake of vitamin B12 seemed to be associated with a delayed sleepwake rhythm [28] and a higher prevalence of insomnia symptoms, assessed by the Insomnia Screening Questionnaire [36]

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& McGehee, M

Tsui, P

Distribution of immunoreactive beta-neo-endorphin in discrete areas of the rat brain and pituitary gland: Comparison with alpha-neo-endorphin