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The mechanism is through activation of the Snail-N-cadherin pathway

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also demonstrated that Asn levels are increased in activated CD8 + T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling

Mutation site residue R152 and active site residues C46, Q81, and W136 are highlighted and shown as white sticks

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase