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[DOI] [PMC free article] [PubMed] [Google Scholar] Dixon DP, Lapthorn A, Madesis P, Mudd EA, Day A, Edwards R

Furthermore, spiculations appear in eryptotic cells, resulting in the loss of their biconcave shape [85]

Folates play an important role in DNA synthesis (through pyrimidine synthesis), protection from DNA damage (though DNA-stabilizing polyamines), and DNA methylation (also through polyamine methyl donors), and upregulated folate metabolism may be indicative of the cells need to repair DNA damage

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