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10.1146/annurev.bi.46.070177.003451 189 SukJ

A single immunization of mice with this vaccine can induce persistent and specific T cell responses, and specific CD8 + T cells can still be detected one year after immunization, which may be related to the ability of Ad5 to induce a lasting effector period [74]

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For instance, oral administration might be subject to first-pass metabolism in the liver, reducing the effective concentration of 5-Amino-1MQ compared to a direct subcutaneous injection