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Histologically, it is characterized by in situ increased production of melanin by basal melanocytes, which are otherwise normal in number and distribution (13), or display increased numbers of melanocytes along the junctional zone in the case of the labial melanotic macules (14)

Transcriptome analysis reveals nonfoamy rather than foamy plaque macrophages are proinflammatory in atherosclerotic murine models

It works well with topical treatments

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