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Biochemistry 48 , 97649774 (2009)

Following the administration of the second injection, a further improvement in the value was observed

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Orally delivered baclofen to control spastic hypertonia in acquired brain injury

One proposed mechanism involves modulation of neurotransmitter systems in the brain, particularly GABAergic, opioidergic, serotonergic, and dopaminergic pathways that are known to regulate sleep, arousal, mood, and stress responses