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Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 109.Li D, Zhang J, Yuan S, Wang C, Chang J, Tong Y, et al

Also, p62 recruited to the damaged mitochondria ubiquitinates Mcl-1, leading to its degradation and activation of apoptosis [305]

"Low plasma antioxidants and normal plasma B vitamins and homocysteine in patients with severe obesity"

In some cases, simpler cellular models such as bacteria and unicellular yeasts can also be used as models, but in many cases their pathways of xenobiotic catabolism are very different from those of mammals thereby limiting their use

Yi & Kaler, 2015)