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Therefore, the increased expression of KLOTHO resulting from treatment with valsartan and fluvastatin may yield highly positive effects in inhibiting cell senescence and promoting overall cellular protection [132, 134] (Table 2)

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In line with this anomaly, adult WT mice exhibit greater resilience to social defeat stress (SDS) than their adolescent counterparts, whereas KI mice sustain heightened anxiety susceptibility throughout adulthooddespite showing no baseline anxiety