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352 A bisubstrate inhibitor comprises two covalently linked fragments, each binding to a substrate or cofactor element, potentially mimicking the ternary transition state of a bireactant-catalyzed reaction

Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition

10.1016/j.jmb.2003.10.053 J Mol Biol

Among transition metals, iron is considered the most critical pro-oxidant in lipid oxidation due to its high reactivity (Gulcin 2012)

Furthermore, these alterations in myelin organization were found to correlate with cognitive impairment in these patients with AD

doi: 10.1017/S0007114511004260