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Probiotics, or live microorganisms that provide health advantages when taken, and prebiotics, nondigestible carbohydrates that encourage beneficial bacteria, are increasingly being employed to modify TMAO synthesis

Bison steak (cooked, 4 oz) Calories: 138 Protein: 17g Fat: 2.8g Saturated Fat: 1.2g Carbohydrates: 0g Potassium: 9% DV Iron: 20% DV Selenium: 31% DV Vitamin B12: 68% DV Zinc: 35% DV Ground bison (cooked, 4 oz) Calories: 200 Protein: 22g Fat: 11g Saturated Fat: 4.5g Carbohydrates: 0g Potassium: 7% DV Iron: 15% DV Selenium: 48% DV Vitamin B12: 86% DV Zinc: 41% DV Nutrient values can vary slightly depending on the cut and the animals diet, but bison consistently delivers a high protein-to-fat ratio and significant micronutrient density

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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]