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This can contribute to the imbalance between the LRRK2PINK1 kinase pair, leading to up-regulation of TH expression, increased DA synthesis, enhanced DA oxidation and aggravation of DA-specific stress in dopaminergic neurons, and dopaminergic neuron vulnerability [44]

doi: 10.1146/annurev.nutr.28.061807.155438

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It has been reported that mutations in K-Ras and PIK3CA frequently occur in colorectal cancer, ~3545% and 20%, respectively
