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Furthermore, AS-IV helps maintain osteo-vascular homeostasis by attenuating oxidative stress and inhibiting apoptosis through activation of the Akt/Nrf2/HO-1 pathway (Shan et al., 2023

Besides their role in inflammation, these cytokines are detrimental to the processes of fertilization and embryo development: TNF- increases the free implants adhesions and their invasiveness through its effect on matrix metallo-proteinases (157) while TGF- hinders the local immune activity by inhibiting the natural killer cells which in turn impede the development of embryos (158)

Takahashi M, Sato T, Shinohara F, Echigo S, Rikiishi H

[1] Most often for at-home therapy, it will be IM injections

Essential oil yield of both Salvia species increased with the decrease in irrigation from 80% to 60% FC but diminished with the more severe water deficit (40% FC)