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This suggests that ferroptosis, in conjunction with pyroptosis ( via NLRP3), may regulate atherosclerosis progression, offering insights into potential therapeutic targets for CAD ( 4.1.4 Non-coding RNAs as biomarkers for ferroptosis in CAD Beyond protein-based biomarkers, non-coding RNAs have emerged as ferroptosis biomarkers relevant to CAD

Shobeiri SF, Sharei S, Heidari A, Kianbakht S

Collagen and matrix biology The first published paper documenting collagen synthesis stimulation by GHK-Cu appeared in 1988: fibroblast cultures increased collagen output when exposed to GHK-Cu at concentrations as low as 10 M, with peak activity around 1 nM (Maquart et al., FEBS Letters, 1988)

However, these conventional techniques have significant limitations

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This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment