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Fucoxanthin activates NRF2 and key redox targets downstream of NRF2, such as the expression of HO-1, SOD and BCL-2, protecting rodent brains from oxidative damage 157 , 158

An 8-week randomized double-blind clinical trial comparing GHK-Cu in nano-lipid carrier to Matrixyl 3000 showed 55.8% reduction in wrinkle volume versus control serum and 31.6% reduction versus Matrixyl 3000, with 32.8% reduction in wrinkle depth versus control

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Although no significant difference in disease-free survival was observed, the improvement in overall survival points to the broad systemic effects of chronic inflammation and its modulation through behavior

It also increases the production of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), which support the survival and growth of neurons