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It is worth examining this carefully because it is the strongest case that can be made, and because it illustrates exactly where mechanistic reasoning shades into overreach

Furthermore, this accumulation was observed as early as 2 months of age and was maintained throughout aging, which may imply that impaired TDP-43 proteostasis is underlying the social and cognitive phenotypes observed in female TDP-43 K408R animals

Curry, S., Mandelkow, H., Brick, P

Phytomedicine 114:154768

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Cornaciu I, Boeszoermenyi A, Lindermuth H, Nagy HM, Cerk IK, Ebner C, et al

ISA can inhibit the proliferation of human umbilical vein endothelial cells (IC 50 = 2.5 g/mL) and the formation of endothelial cell tube in vitro (IC 50 = 1.0 g/mL), indicating its antiangiogenic potential (Ma et al., 2013)