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Wise RA, Holbrook JT, Criner G, Sethi S, Rayapudi S, Sudini KR, Sugar EA, Burke A, Thimmulappa R, Singh A, Talalay P, Fahey JW, Berenson CS, Jacobs MR, Biswal S, Broccoli Sprout Extract Trial Research Group (2016) Lack of effect of oral sulforaphane administration on Nrf2 expression in COPD: a randomized, double-blind, placebo controlled trial

This patient's young age, postpartum status, and diffusely enlarged thyroid without distinct palpable nodules make an activating mutation unlikely

10.1016/j.poly.2020.114424 127

The DNA methylation process of NRF2 regulates its gene expression by adding Me groups to the CpG islands in its promoter region

J Clin Invest 121:42104221

54,55 Because of the existence of the local environment, endothelial cells can together form and maintain the BBB
