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Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 14 An Overview of Similarities and Differences in Metabolic Actions and Effects of Central Nervous System Between Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) and Sodium Glucose Co-Transporter-2 Inhibitors (SGLT-2is) Authors Wen S , Nguyen T, Gong M, Yuan X, Wang C, Jin J, Zhou L Received 24 March 2021 Accepted for publication 15 June 2021 Published 29 June 2021 Volume 2021:14 Pages 29552972 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Konstantinos Tziomalos Song Wen, 1, * Thiquynhnga Nguyen, 1, * Min Gong, 1 Xinlu Yuan, 1 Chaoxun Wang, 1 Jianlan Jin, 1 Ligang Zhou 1, 2 1 Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, Peoples Republic of China

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Many people also saw improvements in other health problems, such as type 2 diabetes, high blood pressure, and high cholesterol

Beyond their structural features, MERCS are established as essential regulatory hubs for a vast array of cellular phenomena

Similarly, in PD, early disease stages are characterized by oxidative stress and heightened proinflammatory responses that exacerbate nigrostriatal degeneration,111,112 with Proinflammatory mediators have also been identified in the substantia nigra of postmortem PD brains.113 Systemic inflammation plays a central role in the pathophysiology of hyperinsulinemia, insulin resistance, and T2DM