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HMGB1 binds to the minor groove of DNA, stabilizing NETs structures, increasing the exposure of CpG motifs, and enhancing the activation of the dual TLR4/TLR9 pathway [115]

We hypothesized that preventing zonulin binding to intestinal epithelia cells decreased the here reported higher intestinal barrier permeability for FITC-Dextran (FD4) along with infiltration of proinflammatory cells in the lamina propria, leading to the prevention of arthritis

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doi: 10.1016/j.jhep.2012.11.045 11 WalterSRTheinHHGiddingHFAminJLawMGGeorgeJet al

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Semaglutide for managing overweight and obesity Recommendations chapter (TA875)