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The mitochondrial fusion/fission-associated proteins Mfn2 and Drp1 have been proposed to function as downstream nuclear transcription factors in the PGC-1-mediated mitochondrial biogenesis process (Peng et al., 2017)

It is produced naturally in our bodies and made from three amino acids- glutamine, glycine, and cysteine

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570,571,572 Increasing NAD + levels by activating the NAD + salvage pathway can inhibit mitochondrial protein hyperacetylation and cardiac hypertrophy and improve cardiac function under stress

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