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Diet has a massive impact

Bif-1 cycles between the cytosol and mitochondria, and during stress it accumulates on the OMM [288], activating autophagosomal biogenesis by interaction with Beclin1 [287]

Because age, low stomach acid, and genetic variation can

de KoningEJvan der ZwaluwNLvan WijngaardenJPSohlEBrouwer-BrolsmaEMvan MarwijkHWet al

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Parkas et al
