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This reaction uses betaine (trimethylglycine) as a methyl donor, which is acquired either by dietary uptake, or as a byproduct of choline degradation [21]

As we age, this recycling process becomes less efficient, meaning we have less active glutathione available when we need it most

This suggests that valproate restores the downregulated expression of glutamate transporters in the spinal cord to reduce glutamate signaling and hypersensitivity after nerve injury

Ferrari R, de Llobet Cucalon LI, Di Vona C, Le Dilly F, Vidal E, Lioutas A, et al