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Their cells are already highly insulin-sensitive, and their system is resilient

[DOI] [Google Scholar] Reddy NM, Kleeberger SR, Bream JH, Fallon PG, Kensler TW, Yamamoto M, Reddy SP

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Further evidence indicates that the absence of ER- leads to accelerated activation and growth of primordial follicles, which in turn precipitates premature exhaustion of ovarian follicular reserves 90