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Characterize off-target effects through selectivity profiling against related receptor subtypes

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115 The researchers found that NPG and CPG exhibited greater stability against trypsin degradation and enhanced antibacterial activity

Residual solvent results should be interpreted against the analytical method used and the relevant solvent class

The altered homeostatic incretin levels in PAR2-G37I or PAR2-R38E versus WT mice were not caused by apparent changes in metabolism, as no significant differences in food and fluid intake, energy expenditure, respiratory exchange ratio, or locomotor activity were observed in indirect calorimetry (Supplemental Figure 2, A and B)