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Randomized, double-blind human trials have shown that GHK-Cu application produces a 55.8% reduction in wrinkle volume and a 32.8% reduction in wrinkle depth compared to controls over 8 weeks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Nobile S., Woodhill J.M

Therefore, there are insufficient exploratory and repeated studies to support a wide recognition of these molecules for their potential in painful disc treatment

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Int J Radiat Oncol Biol Phys 60(2):427-436, 2004