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Instruct patients to contact their health care professionals immediately if they experience any serious side effects while taking any of the fluoroquinolone agents.1,2 The FDA also recommends that prescribers stop systemic fluoroquinolone treatment immediately if a patient reports serious side effects, and to switch to a nonfluoroquinolone antibacterial drug to complete the patient's treatment course.2 Peripheral Neuropathy2 In August 2013, the FDA required the drug labels and Medication Guides for all fluoroquinolone antibacterial drugs to be updated to more fully explain the serious side effect of peripheral neuropathy, a nerve disorder of the arms or legs

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We set those thresholds so that we assign roughly a third of 30-day periods within each clinical group to each functional impairment level (low, medium, or high)

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