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The cells were then lysed and centrifuged at 20000 g for 10 min at 4 C to remove cellular debris

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While heterologous desensitization of the 2 AR was mediated primarily by PKA, a novel catecholamine-activated cAMP-independent kinase, termed AR kinase (ARK, later named GRK2), was responsible for the process of homologous desensitization [11, 12]

Of these, 73% sought to change the underlying biology of Alzheimer's disease