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Reduced the dosage by no more than 0.5 mg every 3 days

This approach effectively lowers inflammatory factor expression levels following PEID, alleviates postoperative low back and leg pain symptoms, reduces hospital stay duration, and accelerates recovery

doi: 10.1039/c5sc01501d

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PfB and BruB were shown to catalyze regioselective and stereoselective electrocyclization of polyene products from the respective PKS-NRPS, followed by either a [4+2] cycloaddition to give ()-PF-1018 ( 285 ), or [3,3]-Cope rearrangement to give 286 , respectively (Figure 62)

Holland et al