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Context-dependent functional differences among AREs fit with findings from another group that combined high-throughput promoter-dependent drug screens and transcriptomics analyses to uncover that low doses of the chemotherapeutic doxorubicin downregulate cell cycle genes while high doses upregulate DNA damage response genes

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Medina MF, Castro G, Falcon F, Cabello JF, Faundes V, Ruffato D et al (2021) Maple syrup urine disease: characteristics of diagnosis and treatment in 45 patients in Chile