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In contrast, a worsened clinical course, higher hypermagnesemia, and emerging hyperkalaemia might cause both l-NAME and l-arginine to affect the same events adversely

Last reviewed: May 28, 2026 Last updated: May 28, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

doi: 10.7326/0003-4819-122-8-199504150-00001

Three primary routes have been explored: transBBB transport, intranasal administration, and intrathecal delivery

GAD, the enzyme that catalyzes the formation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), has two forms GAD65 and GAD67, expressed by two different genes (Erlander et al