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In this case, the recruited cells may serve as a physical barrier to prevent later immune cells from approaching and attacking the tumor cells Also, the recruited immune cells can also secrete cytokines (such as IL1-, TGF-) that continue to assimilate later recruited immune cells as tumor-friendly phenotypes (16, 17)

3A, [8284]

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Statistical analysis The experimental data were analyzed by the Statistical Package for the Social Sciences (SPSS, IBM, version 19.0) and determined by parametric (LSD test) and non-parametric (Wilcoxon) tests, based on residual normality (Gaussian distribution) and variance homogeneity