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Supportive care remains the cornerstone of therapy In early stage of this acute disease patient should be admitted to hospital for observation because the ascending paralysis may rapidly involve respiratory muscles Patients with slow progression may simply be observed for stabilization and spontaneous remission without treatment Rapidly progressive ascending paralysis is treated with intravenous immunoglobulin IVIG Each day counts after 1st motor symptom till 2 weeks, when treatment may be effectiveEither IvIg or Plasmapharesis, IvIg choosen for ease of administration & good saftey record GBS autoantibodies are neutralized by anti-idiotypic antibodies present in IVIg preparations Lack of noticeable improvement following IVIg or PE is not an indication to treat with the alternate one.In worsening case critical care monitoring for vital capacity, heart rhythm, blood pressure, nutrition, deep vein thrombosis prophylaxis, early consideration (after 2 weeks of intubation) for tracheostomy, and chest physiotherapySome may need temporary venous pacemaker Frequent turning, assiduous skin care, physiotherapy for joint contracture

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Clopidogrel down-regulated the VEGF-A and VEGFR1 , subsequently inactivated AKT signaling pathway and induced phosphorylation of p38/MAPK and ERK/MAPK

Its important to stick to a set protocol for injecting Vitamin B12