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As above-mentioned, TMAO increases intracellular ROS, and ROS activates NF-B signaling by triggering the IKK complex, leading to IB phosphorylation and degradation

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Aliquots of blood and urine were frozen at 80 C and thawed up to three times

A total of 858 cases of DILI were identified, of which, 47 were identified in the setting of statin use, 16 were attributed to atorvastatin, 13 to simvastatin, 12 to fluvastatin, four to lovastatin, and two to pravastatin