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Currently, two main theories are widely accepted, including the trigeminovascular system (TGVS) theory and the cortical spreading depression (CSD) theory

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Similarly, human studies revealed an up-regulation of IL-17A, IL-6, and IL-8 cytokines in the peripheral blood of asthmatic patients, which was positively associated with gastrointestinal symptoms

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However, conflicting studies have suggested that ACEI drugs may not have a significant impact on blood lipids [100]

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