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Rationalization of the pKa values of alcohols and thiols using atomic charge descriptors and its application to the prediction of amino acid pKas

The C-terminal Gly domain of hnRNP A1 is important for the binding

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Tirzepatide works, but stopping it reverses the gains

Exacerbation of alcohol-induced oxidative stress in rats by polyunsaturated Fatty acids and iron load

Meanwhile, single-cell RNA sequencing (scRNA-seq) has revealed that stem-like cell populations with elevated OXPHOS activity contribute to drug resistance and metastatic potential, providing direct evidence for the cellular basis of metabolic heterogeneity in CRC [166, 167]
