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For instance, the outer membrane of Gram-negative bacteria acts as a barrier that prevents many drugs from entering the cell

[DOI] [PubMed] [Google Scholar] 280.Rengel R.G., Filipovi-Grci J., Cepelak I., Zani-Grubisi T., Barisi K

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Adding to the paracellular movement of drugs across capillaries is the bulk flow of water that moves in relation to the net balance of hydrostatic and osmotic forces between the vascular and interstitial compartments
