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Lipid peroxidation increases ROS generation and damages cell membranes, activating a series of pro-apoptotic signaling molecules (e.g., caspase-3, p53), which lead to muscle cell apoptosis

Cancer Res 56(5):11111117 Dirkx AE et al (2003) Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression

Genetic variants in MBOAT7 have been identified as a significant risk that may contribute to the abnormal formation of lipid droplets that promote liver injury, inflammation, and the development and progression of MASLD [273]

We first came across LightEyez in early 2023 and reported them to the FDA

doi: 10.1038/nature16504 73
