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However, only 22% of the variation in MMA levels was explained by vitamin B12, estimated glomerular filtration rate, age, sex, and socioeconomic status, suggesting that other underlying disease was likely the reason for elevated MMA levels

however, two more trials reported no alterations in plasma vitamin A levels post-treatment [91, 96]

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For example, conventional chondrogenic factors (Jonitz et al., 2012), epigenetic manipulation with specific agents (Duan et al., 2017), or co-culture with mesenchymal stem cells (Lai et al., 2013), have been shown to promote or maintain chondrocytic phenotype