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Drug Metab Dispos 41:550553

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Researchers have discovered a potent and selective glutamine transporter inhibitor, V9302, which specifically targets the SLC1A5 and effectively inhibits glutamine uptake [191].SLC1A5 has been reported to be involved in the modulation of the immune microenvironment in multiple types of tumors

The rationale for these findings lies in the metabolic shift from glucose to ketone bodies: since cancer cells are metabolically reliant on glycolysis, ketosis deprives them of their primary energy source, potentially slowing their growth

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Over a period of months, much of the initial disability can be compensated for (70
