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511,4956 Reversible PD phenomenon The PD clinical course is typically described as irreversible PN

This notion is supported by the observation that restriction of heme release using different approaches, such as binding of Hb to Hp or strengthening the globin-heme binding, inhibits the deleterious effects of these Hb species (Balla et al., 2002

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(2005) 289:G37780

Background An increasing trend of Parkinson's disease (PD), as the neurodegenerative illness, has been reported, and it is more prevalent in countries with high human development and sociodemographic indicators (1)
