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The immune system hypothesis includes the alteration of the proper functioning of the central nervous system (CNS) associated with an abnormal response to common antigens, stimulation of the inflammatory and cell-mediated immune responses, and upstream regulation of oxidative and nitrosative pathways, and autoimmune responses against neuronal and other cells (Marshall-Gradisnik et al
Newton TF, De La Garza R Jr, Kalechstein AD, Tziortzis D, Jacobsen CA (2009) Theories of addiction: methamphetamine users' explanations for continuing drug use and relapse

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Data collection, analysis and interpretation of data and literature review were done by UR, KPJ, and EMME.UR and AMSDMD guided the other authors in data analysis, interpretation and corrected the final manuscript

It is important to note that most biomarker studies to date are based on analyses of group information, rather than at the level of the individual patient

The first enzyme, glutamatecysteine ligase (GCL) formerly called -glutamylcysteine synthase (GCS) is the rate-limiting enzyme