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Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium

Admittedly, this approach may affect our findings, producing a bias in the treatment estimation [30]

Melanotan is a synthetic peptide similar to a substance in our bodies, known as melanocyte-stimulating hormone, which increases the production of skin-darkening pigments

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Collectively, these cells form a polarized layer to establish a tight barrier by virtue of intracellular tight junctions, adherens junctions, and desmosomes